The tears, the blood and ruins of the war left a big weight on Koreans' shoulders, one which was reflected on the many difficulties the country went through during those years. Yet, it was one of the most prolific artistic periods the country ever went through, especially in its cultural center Myeongdong, Seoul. All the trends started there, from that parade of feebly lit streets, the fog-like cigarette smoke and the sound of that decade enveloping the whole district. "The Count of Myeongdong" is not your average drama with a normal story, a beginning and a conclusion, a few characters dominating it. It's more of a docu-drama, a love letter to the Myeongdong that shone between 1953 and 1960. All the coffee shops, the theaters, the publishing companies and even television stations, and all the stars making Myeongdong great. Poets, novelists, musicians, journalists, and their romantic, tragic and crazy lives.

Jung Min Joo is a woman from a very tough family background. Her mother had three children with three different fathers. However, she overcomes this in order to become a news announcer. When she first meets Kim Joon Sung, she is annoyed with his continued courtship of her. Eventually, Min Joo marries Joon Sung and her life changes. Her aspirations of becoming a great reporter are put on hold while she copes to her new life as the second daughter-in-law of a rich and influential chaebol family.

Cha Young Jin is the first female to ever work as a bodyguard in the Presidential resident, Chungwadae. Young Jin and Yoo Gwang Pil work as bodyguards assigned to watch over the president's son, Kang Soo Ho. They are assigned to guard Soo Ho for 15 months.

Han Geon Soo is the young clinic owner who tries to protect his clinic from being taken over by loan sharks. He tries his best to save the clinic when uncollected loans are passed on to him after his father's sudden death. Choi Yong Woo is a talented doctor who joins the clinic to return his thanks to Geon Soo's father. Yong Woo is someone that often gets into arguments with patients who want to undergo unnecessary plastic surgery. Yoon Ki Nam is the nurse who forms a love triangle between the two men. Yoon Seo Jin is the manager who obtained her perfect beauty through plastic surgery.

Han Do Kyung, specially scouted by the Incheon Airport Director, willingly accepted 1/3 of the pay she was receiving when working in Singapore to come back to Korea as the chief of operations of Incheon Airport. She speaks five different languages. However, Do Kyung lives with an uneven wound of her family and a regret of leaving her sister behind. She met Kim Ji Sung, a National Intelligence Service agent and gets entangle with him. Kim Ji Sung is very passionate about his work to the extend that he is willing to bend the rules to ensure the security of the country even if he is only acting on his instincts. After being stationed at the airport, he finds himself in an emotional turmoil with a woman he used to love who is also working in the airport. At the same time, he is falling for Han Do Kyung. Kang Ha Joon, a childhood friend of Han Do Kyung is also falling for Do Kyung. Kang Ha Joon is a quick tempered with a habit of talking aggresively due to his nature of work watching over thousands of surveilance cameras in the airport but has good relations with all the airport employees even the cleaners because of his kind personality outside of work. As his friendship develops with Do Kyung, he becomes a strong source of refuge for her. But as his feelings for her grows, his relationship gets more and more complicated with a woman who is his friend, superior at workplace and unrequited love.

Ban Ha Jin (Lee Dong Gun), an orphan and high school drop out, is calculating and ambitious. Even though he dropped out of high school and lives with Choi Yoo Kang (Yoon Se Ah) due to extenuating circumstances, he used to be the high school president and hoped to go to college. Through coincidence, he meets Yoon Jae Myung (Lee Jin Wook), the popular former baseball player from high school, at a bar in Switzerland. Ha Jin manipulates a series of events to become Jae Myung's best friend. Also coincidentally, he meets Oh Dan Hui (Kim Hee Sun), the girl he loved and hurt in high school. Oh Dan Hui used to play baseball on the boy's team but now plays softball in college. Her baseball hero is Yoon Jae Myung. All three meet again in Switzerland and again back in Korea. Ha Jin starts working in Jae Myung's father's company and does everything to make the rich chairman like him. Jae Myung starts working as the softball coach of his father's company's team but then gets transferred. He falls in love with Dan Hui who's headstrong and optimistic personality attracts him. He asks Ha Jin for advice, but Ha Jin cannot bear to watch Jae Myung take his true love.

Yoo Eun Ho (Son Yeh Jin), an instructor at a fitness club divorced her husband Lee Dong Gin (Kam Woo Sung) after the death of their new born baby as she blamed him for not being there for her when she needed him most. They remained friends after the divorce and met regularly. Even though both started seeing other people, they still had great feelings towards each other. With the help of YEH's sister Yoo Ji Ho (Lee Ha Na) and LDG's friend, Dr. Gong Jeon pyo (Gong Hyeong Gin), they finally realized that they should get back together.