Lee Yeon gets involved in an unexpected case that leads him to travel back in time to the year 1938. There, Lee Yeon meets Ryu Hong Joo again. She was once a guardian spirt of a mountain in the west, but in 1938 she is the owner of the best high-end restaurant Myoyeongak in the capital city of Gyeongseong. When Ryu Hong Joo met Lee Yeon for the first time, she was fascinated by him, but she couldn’t have him. Now, she meets him again and she feels excitement. Lee Yeon also meets his younger brother Lee Rang. Meanwhile, Cheon Moo Young used to be a guardian spirit of a mountain in the east and he used to be friends with Lee Yeon and Ryu Hong Joo. A case led Cheon Moo Young to become hostile towards him. Lee Yeon struggles to go back to the present day where his loved one lives.
Kim Sa Bu was once a famous surgeon at the peak of his career at a major hospital. But he suddenly gives it all up one day to live in seclusion and work as a neighborhood doctor in a small town. He now goes by “Teacher Kim” and refers to himself as the “Romantic Doctor”.
Meanwhile, Kang Dong Joo became a doctor to make something of himself after growing up poor, and he seeks out VIP patients to achieve the success that he desperately wants. Yoon Seo Jung is a passionate young surgeon who is haunted by a mistake from her past and tries to get over it. When Dong Joo and Seo Jung meet the quirky Teacher Kim, their lives and careers will never be the same again.
Yoon Hae Joon started his career at a broadcasting station as a local news reporter. He now works an anchor for the weekend news program and is the youngest anchor to ever work at the broadcasting station. He is calm and straightforward as a journalist and kind to people in his personal life.
Baek Yoon Young dreamed of becoming a writer, but, to support herself, she works at a publishing company. She is under a lot of stress because of her job and she sometimes takes it out on her mother. One day, Baek Yoon-Young faces a shocking case that changes her life.
Yoon Hae Joon and Baek Yoon Young somehow both travel back in time to the year 1987. There, Yoon Hae Joon tries to find the truth behind a serial murder case and Baek Yoon Young tries to prevent her parents from marrying. Their goals seem completely unrelated, but they soon realize that their objectives are connected.
The war of jealousy and desire of four friends, one of them became a murderer due to lies of the others 10 years ago and appeared in front of the three successful friends.
Young Soon is a single mother and pig farmer who raised her son Kang Ho alone. Despite her love for him, her strict parenting caused Kang Ho to view her as a bad mother. As an adult, Kang Ho became a cold-hearted prosecutor and kept his distance from his mother. However, an unexpected accident caused him to return to his hometown and start over with Young Soon. Kang Ho's childhood friend Mi Joo, known for her warm heart and strong sense of justice, also reconnected with him after his accident, leading to a transformative experience for her.
Cha Jung Sook is married to Seo In Ho, who works as a chief surgeon at a university hospital. He has a strict, sensitive and thoroughgoing personality. Cha Jung Sook has been a full time housewife for the past 20 years, giving up her career as a doctor during her medical resident years. After all those years, she decides to restart her medical resident course.