Jin Hyuk is a genius neurosurgeon with a cold and severe attitude in his interactions with other people due to his personal pursuit of perfection. Through a mysterious power, Jin Hyuk finds himself transported back in time 150 years. He begins treating people there, but the lack of necessary implements and rudimentary medical knowledge of the period forces him to seek new ways to aid the sick. Through this challenging process, Jin Hyuk eventually becomes a genuine doctor.

The drama portrays the life of Lee Kang Mo through his early teens to his early 40s.

This new drama is about the behind the scenes of TV drama production. It also portrays how the whole production team and performers complete a project in a tight schedule and as well as how actors, actresses, and entertainment agencies handle rumors surrounding them. Jang Ki Joon is a manager who is in charge of the activities of many famous actors and actresses and one of them is Oh Seung Ah who is a rising actress. Lee Kyung Min is a drama PD, and Seo Young Eun is a script writer with a young son.

Bong Dal Hee (Lee Yo Won) is a first year resident doctor who strives to become a surgeon despite her heart problem. She works under Dr. Ahn Jong Geun (Lee Bum Soo), a cardiac specialist, and even though they don't get off to a good start, the two grow fond of each other as time goes by. Dr. Lee Geon Wook (Kim Min Joon) divorced his wife, Dr. Jo Moon Kyung (Oh Yoon Ah), after he found out that his 6-year-old son was actually fathered by another man before they married. He still has feelings for her, but feels betrayed and cheated. This medical drama portrays the lives of resident doctors, their ups and downs, depicting crisis in a hospital as well as politics among its management staff.