This drama is about the tumultuous lives of three sisters. Jo Young Ran is trapped in a loveless marriage to her cold and uncaring husband, whom she married after dating for a week. Her older sister Young Shim's poor financial situation and desire to live a rich and glamorous life causes her to quarrel frequently with her husband, while her younger sister Young Mi has a good career is married to a mother's boy.

A comedy romance drama about potential son in-laws who come finding their way to the doorsteps of their future wives because of fate. Jo Gi Dong is a guy who causes some chaotic situations when he aims to become the son in-law of a rich man portrayed by Joo Hyun. Han Mi Soo is a rich girl who falls for Gi Dong. Kim Seung Soo plays Mi Soo's first love in college.

Bong Dal Hee (Lee Yo Won) is a first year resident doctor who strives to become a surgeon despite her heart problem. She works under Dr. Ahn Jong Geun (Lee Bum Soo), a cardiac specialist, and even though they don't get off to a good start, the two grow fond of each other as time goes by. Dr. Lee Geon Wook (Kim Min Joon) divorced his wife, Dr. Jo Moon Kyung (Oh Yoon Ah), after he found out that his 6-year-old son was actually fathered by another man before they married. He still has feelings for her, but feels betrayed and cheated. This medical drama portrays the lives of resident doctors, their ups and downs, depicting crisis in a hospital as well as politics among its management staff.

Yoon Hyun Suh (played by Ahn Jae Wook) is an adoptee who grows up in the United States. He becomes successful as a top manager of a hotel chain. He is assigned to do business in Korea. He falls in love with Choi Young In (played by Lee Bo Young), a sassy concierge from the hotel he is assigned to. There is trouble still looming because Kang Soo Jin (played by Oh Yoon Ah) who is Hyun Suh's best friend's ex-wife comes back with vengeance in mind. The three become entagled in this love triangle.